Invention Grant
US08759310B2 Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8
有权
用于TLR7和TLR8的稳定免疫调节RNA（SIMRA）化合物
- Patent Title: Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8
- Patent Title (中): 用于TLR7和TLR8的稳定免疫调节RNA（SIMRA）化合物
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Application No.: US13353905Application Date: 2012-01-19
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Publication No.: US08759310B2Publication Date: 2014-06-24
- Inventor: Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
- Applicant: Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
- Applicant Address: US MA Cambridge
- Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wood, Philips, Katz, Clark & Mortimer
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K49/00 ; A61K39/00 ; A61K45/00 ; A61K47/00 ; C07H21/04
Abstract:
The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
Public/Granted literature
- US20130202584A1 STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 Public/Granted day:2013-08-08
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