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US08759317B2 Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP) 有权
使用鸟苷3'，5'环状单磷酸（环状GMP）治疗癌症的方法

Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)
Abstract:
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.
Abstract(Chinese):

通过使用鸟苷3'，5'-环状单磷酸（循环GMP）治疗癌症的方法。 循环GMP减少30％（1μM），84％（1mM），31％（1μM）和30％（1μM）的人乳腺癌和前列腺腺癌以及小细胞和鳞状肺细胞数 1μM）。 循环GMP分别在人胰腺，乳腺和前列腺腺癌以及其1μM浓度的肺细胞和鳞状细胞癌中分别减少51％，54％，56％，50％和52％的DNA合成。 循环GMP输注一周时，与无胰腺腺癌的未经治疗的动物相比，无胸腺小鼠的人胰腺腺癌的肿瘤体积减少了95％。

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