Invention Grant
- Patent Title: Aminopyrimidines as SYK inhibitors
- Patent Title (中): 氨基嘧啶类作为SYK抑制剂
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Application No.: US13516455Application Date: 2010-12-15
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Publication No.: US08759366B2Publication Date: 2014-06-24
- Inventor: Kaleen Konrad Childers , Andrew M. Haidle , Michelle R. Machacek , Alan B. Northrup
- Applicant: Kaleen Konrad Childers , Andrew M. Haidle , Michelle R. Machacek , Alan B. Northrup
- Applicant Address: US NJ Rahway CA Quebec
- Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee Address: US NJ Rahway CA Quebec
- Agent Eric A. Meade; Valerie J. Camara
- International Application: PCT/US2010/060454 WO 20101215
- International Announcement: WO2011/075515 WO 20110623
- Main IPC: C07D417/12
- IPC: C07D417/12 ; A61K31/497
Abstract:
The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
Public/Granted literature
- US20120277192A1 AMINOPYRIMIDINES AS SYK INHIBITORS Public/Granted day:2012-11-01
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