Invention Grant
- Patent Title: Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
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Application No.: US13378800Application Date: 2010-07-01
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Publication No.: US08759368B2Publication Date: 2014-06-24
- Inventor: Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
- Applicant: Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
- Applicant Address: US IA Coralville
- Assignee: KemPharma, Inc.
- Current Assignee: KemPharma, Inc.
- Current Assignee Address: US IA Coralville
- Agency: McAndrews, Held & Malloy, Ltd.
- International Application: PCT/US2010/040775 WO 20100701
- International Announcement: WO2011/002991 WO 20110106
- Main IPC: A61K31/485
- IPC: A61K31/485
Abstract:
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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