Invention Grant
- Patent Title: Chromene modulators of chemokine receptor activity
- Patent Title (中): 趋化因子受体活性的色调调节剂
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Application No.: US13003777Application Date: 2009-07-14
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Publication No.: US08759390B2Publication Date: 2014-06-24
- Inventor: Douglas G. Batt
- Applicant: Douglas G. Batt
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Laurelee A. Duncan
- International Application: PCT/US2009/050450 WO 20090714
- International Announcement: WO2010/009069 WO 20100121
- Main IPC: C07D311/60
- IPC: C07D311/60 ; A61K31/35

Abstract:
The present application describes modulators of MCP-1 or CCR-2 of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W1, W2, W3, Y, Z, R2, R3, R3′ and R4, are defined in the specification. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
Public/Granted literature
- US20110112146A1 CHROMENE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Public/Granted day:2011-05-12
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