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US08759390B2 Chromene modulators of chemokine receptor activity 有权
趋化因子受体活性的色调调节剂

  • Patent Title: Chromene modulators of chemokine receptor activity
  • Patent Title (中): 趋化因子受体活性的色调调节剂
  • Application No.: US13003777
    Application Date: 2009-07-14
  • Publication No.: US08759390B2
    Publication Date: 2014-06-24
  • Inventor: Douglas G. Batt
  • Applicant: Douglas G. Batt
  • Applicant Address: US NJ Princeton
  • Assignee: Bristol-Myers Squibb Company
  • Current Assignee: Bristol-Myers Squibb Company
  • Current Assignee Address: US NJ Princeton
  • Agent Laurelee A. Duncan
  • International Application: PCT/US2009/050450 WO 20090714
  • International Announcement: WO2010/009069 WO 20100121
  • Main IPC: C07D311/60
  • IPC: C07D311/60 A61K31/35
Chromene modulators of chemokine receptor activity
Abstract:
The present application describes modulators of MCP-1 or CCR-2 of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W1, W2, W3, Y, Z, R2, R3, R3′ and R4, are defined in the specification. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
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