Invention Grant
US08759485B2 Chemokine binding activity of viral TNF receptors and related proteins
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病毒TNF受体和相关蛋白的趋化因子结合活性
- Patent Title: Chemokine binding activity of viral TNF receptors and related proteins
- Patent Title (中): 病毒TNF受体和相关蛋白的趋化因子结合活性
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Application No.: US11661633Application Date: 2005-09-02
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Publication No.: US08759485B2Publication Date: 2014-06-24
- Inventor: Antonio Alcami Alcami Pertejo , Ali Alejo Herberg , Maria Begona Ruiz-Arguello , Yin Ho , Margarida Saraiva , Vincent P. Smith
- Applicant: Antonio Alcami Alcami Pertejo , Ali Alejo Herberg , Maria Begona Ruiz-Arguello , Yin Ho , Margarida Saraiva , Vincent P. Smith
- Applicant Address: ES Sebastian de Reyes
- Assignee: Antonio Alcami Pertejo
- Current Assignee: Antonio Alcami Pertejo
- Current Assignee Address: ES Sebastian de Reyes
- Agency: Leason Ellis LLP
- Priority: ES200402123 20040902
- International Application: PCT/EP2005/009449 WO 20050902
- International Announcement: WO2006/024533 WO 20060309
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00 ; C12P21/04 ; A61K38/00 ; A61K38/16 ; A61K39/00
Abstract:
Chemokine binding activity of viral TNF receptors and related proteins. The invention relates to a C-terminal domain (CTD) of viral tumor necrosis factor receptors (vTNFRs) CrmB or CrmD or CTD homologues (CTD1, CTD2 and CTD3) from poxvirus and their functional homologues, including derivatives, and fragments, for use in binding chemokines and their analogues and/or to enhance the immunomodulatory properties of TNFRs or in blocking binding of chemokines to their corresponding cell surface receptors and/or to modulate chemokine biological activity.
Public/Granted literature
- US20090104178A1 Chemokine binding activity of viral tnf receptors and related proteins Public/Granted day:2009-04-23
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