Invention Grant
US08759507B2 Modulation of exon recognition in pre-mRNA by interfering RNA structure
有权
通过干扰RNA结构调节前mRNA的外显子识别
- Patent Title: Modulation of exon recognition in pre-mRNA by interfering RNA structure
- Patent Title (中): 通过干扰RNA结构调节前mRNA的外显子识别
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Application No.: US12976381Application Date: 2010-12-22
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Publication No.: US08759507B2Publication Date: 2014-06-24
- Inventor: Judith Christina Theodora Van Deutekom
- Applicant: Judith Christina Theodora Van Deutekom
- Applicant Address: NL Leiden
- Assignee: Academisch Ziekenhuis Leiden
- Current Assignee: Academisch Ziekenhuis Leiden
- Current Assignee Address: NL Leiden
- Agency: Sunstein Kann Murphy & Timbers LLP
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA.
Public/Granted literature
- US20110312086A1 MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE Public/Granted day:2011-12-22
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