Invention Grant
- Patent Title: Cyclobutyl sulfones as notch sparing gamma secretase inhibitors
- Patent Title (中): 环丁基砜作为缺口保护性γ分泌酶抑制剂
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Application No.: US12989131Application Date: 2009-04-17
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Publication No.: US08759579B2Publication Date: 2014-06-24
- Inventor: Richard W. Heidebrecht , Chaomin Li , Benito Munoz , Andrew Rosenau , Laura M. Surdi , Paul Tempest
- Applicant: Richard W. Heidebrecht , Chaomin Li , Benito Munoz , Andrew Rosenau , Laura M. Surdi , Paul Tempest
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent J. Eric Thies; John C. Todaro
- International Application: PCT/US2009/040913 WO 20090417
- International Announcement: WO2009/131906 WO 20091029
- Main IPC: C07C311/13
- IPC: C07C311/13 ; C07C61/16 ; A61K31/195 ; A61K31/18
Abstract:
The invention encompasses a novel class of cyclobutyl sulfone derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
Public/Granted literature
- US20110039925A1 CYCLOBUTYL SULFONES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS Public/Granted day:2011-02-17
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