Systems and associated methods for monitoring and/or controlling access to interior portions of consumer-operated kiosks and other enclosures are disclosed herein. In one embodiment, a consumer-operated kiosk includes an enclosure having a door movable between a closed position that prevents access to the enclosure and an open position that permits access to the enclosure. In this embodiment, an identifier, such as an RFID transponder or tag, is mounted to one of the enclosure or the door, and a reader, such as an RFID reader, is mounted to the other of the enclosure or the door. When the door is closed, the reader detects the identifier. Conversely, when the door moves away form the closed position, the reader ceases to detect the identifier and can generate/send a signal indicating that the door is open.