Symmetrical or asymmetrical noise distributions for voltages corresponding to symbols that can be stored in multi-level memory cells (MLCs) of a memory device are used to determine read reference and/or programming voltages. The read reference voltages and/or programming voltages for the MLCs are jointly determined using the symmetrical distributions and a maximum likelihood estimation (MLE) and/or by determining at least one of the read reference voltages and the programming voltages using the asymmetrical distributions.