A method of detecting a skin condition may include employing a multiband hyperspectral sensor to obtain multi-spectral data, employing the multi-spectral data to map constitutive skin parameters to corresponding spectral signatures via a forward model that enables generation of a set of samples including a plurality of parameters mapped to a plurality of spectral signatures, utilizing the set of samples to employ machine learning to generate an inverse model to enable mapping of a spectral signature of skin of a patient to corresponding skin parameters, estimating constitutive skin parameters of the skin of the patient based on the inverse model, and determining a distribution of the constitutive parameters for one or more skin locations.