A system and method for analyzing and visualizing spectral CT data includes access of a set of image data acquired from a patient comprising spectral CT data, identification of a plurality of target regions of interest (TROIs) and a reference region of interest (RROI) from the set of image data, extraction of a plurality of target spectral Hounsfield unit (HU) curves from image data representing the plurality of TROIs, extraction of a reference spectral HU curve from image data representing the RROI, normalization of the plurality of target spectral HU curves with respect to the reference spectral HU curve, and display of the plurality of normalized target spectral HU curves.