An example game device arranges, in a game space, a plurality of first characters corresponding to a plurality of controllers and a second character corresponding to a portable display device. The second character is caused to move in the game space based on an input operation performed on an analog stick. An orientation of the second character is changed based on an input operation performed on the analog stick and an input operation performed on a change in an attitude of the portable display device. On the other hand, the first character is caused to normally automatically move along a predetermined path, and to move toward an enemy character when the enemy character is present within a predetermined range.