A method of repositioning an injection port comprises positioning the injection port at a first location in a patient's body and extending fasteners of the injection port to substantially secure the injection port at the first location. The fasteners are then retracted to substantially unsecure the injection port from the first location in the patient's body. The injection port is then moved to a second location in the patient's body. The fasteners are then re-extended to substantially secure the injection port at the second location in the patient's body. The injection port includes a port body. The fasteners are integral with the port body. The fasteners may be selectively extended and retracted relative to the port body. For instance, the fasteners may be pivoted relative to the port body to transition between extended and retracted positions. The extension and retraction of fasteners may be provided through a port applier.