Invention Grant
US08764968B2 DNA sequencing using multiple metal layer structure with organic coatings forming transient bonding to DNA bases
有权
使用多层金属层结构进行DNA测序，其中有机涂层形成与DNA碱基的瞬时键合
- Patent Title: DNA sequencing using multiple metal layer structure with organic coatings forming transient bonding to DNA bases
- Patent Title (中): 使用多层金属层结构进行DNA测序，其中有机涂层形成与DNA碱基的瞬时键合
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Application No.: US13607070Application Date: 2012-09-07
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Publication No.: US08764968B2Publication Date: 2014-07-01
- Inventor: Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
- Applicant: Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
- Applicant Address: US NY Armonk
- Assignee: International Business Machines Corporation
- Current Assignee: International Business Machines Corporation
- Current Assignee Address: US NY Armonk
- Agency: Cantor Colburn LLP
- Agent Vazken Alexanian
- Main IPC: G01N27/327
- IPC: G01N27/327
Abstract:
A technique for nanodevice is provided. A reservoir is filled with an ionic fluid. A membrane separates the reservoir, and the membrane includes electrode layers separated by insulating layers in which the electrode layers have an organic coating. A nanopore is formed through the membrane, and the organic coating on the electrode layers forms transient bonds to a base of a molecule in the nanopore. When a first voltage is applied to the electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base.
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