Invention Grant
- Patent Title: Anti-hepcidin antibodies and uses thereof
- Patent Title (中): 抗铁调素抗体及其用途
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Application No.: US13708059Application Date: 2012-12-07
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Publication No.: US08765129B2Publication Date: 2014-07-01
- Inventor: Donmienne Doen Mun Leung , Peng Luan , Barbara Anne Swanson , Ying Tang , Derrick Ryan Witcher
- Applicant: Eli Lilly and Company
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Robert L. Sharp
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
Public/Granted literature
- US20130164304A1 ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF Public/Granted day:2013-06-27
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