Invention Grant
- Patent Title: Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
- Patent Title (中): 具有改变的干扰素拮抗剂活性的减毒负链病毒用作疫苗和药物
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Application No.: US13250846Application Date: 2011-09-30
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Publication No.: US08765139B2Publication Date: 2014-07-01
- Inventor: Peter Palese , Adolfo Garcia-Sastre , Thomas Muster
- Applicant: Peter Palese , Adolfo Garcia-Sastre , Thomas Muster
- Applicant Address: US NY New York
- Assignee: Icahn School of Medicine at Mount Sinai
- Current Assignee: Icahn School of Medicine at Mount Sinai
- Current Assignee Address: US NY New York
- Agency: Jones Day
- Main IPC: A61K39/145
- IPC: A61K39/145 ; A61K39/12 ; A01N63/00 ; A61K39/38 ; A61K39/25
Abstract:
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. The invention also relates to the development and use of IFN-deficient systems for selection of such attenuated viruses.In particular, the invention relates to attenuated influenza viruses having modifications to the NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. The mutant viruses replicate in vivo but demonstrate reduced pathogenicity, and therefore are well suited for live virus vaccines, and pharmaceutical formulations.
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