Invention Grant
- Patent Title: DNA vaccine compositions with HIV/SIV gene modifications
- Patent Title (中): 具有HIV / SIV基因修饰的DNA疫苗组合物
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Application No.: US13185148Application Date: 2011-07-18
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Publication No.: US08765140B2Publication Date: 2014-07-01
- Inventor: Opendra Narayan , Zhenqian Liu
- Applicant: Zhenqian Liu
- Applicant Address: US KS Kansas City
- Assignee: University of Kansas Medical Center
- Current Assignee: University of Kansas Medical Center
- Current Assignee Address: US KS Kansas City
- Agency: Polsinelli PC
- Agent Kimberly A. Honeycutt
- Main IPC: A61K39/21
- IPC: A61K39/21 ; A61K39/12 ; C07H21/04
Abstract:
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3′ LTR.
Public/Granted literature
- US20120020999A1 DNA Vaccine Compositions with HIV/SIV Gene Modifications Public/Granted day:2012-01-26
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