Invention Grant
US08765145B2 LSA-5 liver stage and blood stage antigen of Plasmodium falciparum, immunogenic composition comprising said antigen, and vaccines against malaria
有权
LSA-5肝阶段和恶性疟原虫的血液抗原，包含所述抗原的免疫原性组合物和抗疟疾疫苗
- Patent Title: LSA-5 liver stage and blood stage antigen of Plasmodium falciparum, immunogenic composition comprising said antigen, and vaccines against malaria
- Patent Title (中): LSA-5肝阶段和恶性疟原虫的血液抗原，包含所述抗原的免疫原性组合物和抗疟疾疫苗
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Application No.: US11451324Application Date: 2006-06-13
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Publication No.: US08765145B2Publication Date: 2014-07-01
- Inventor: Pierre Druilhe , Karima Brahimi-Zeghidour
- Applicant: Pierre Druilhe , Karima Brahimi-Zeghidour
- Applicant Address: SG Singapore
- Assignee: Vac-4-All Pte. Ltd.
- Current Assignee: Vac-4-All Pte. Ltd.
- Current Assignee Address: SG Singapore
- Agency: Morgan, Lewis & Bockius LLP
- Priority: EP03293158 20031215
- Main IPC: A61K39/002
- IPC: A61K39/002
Abstract:
The present invention pertains to the protection against malaria. More particularly, the invention is based on the characterization of a novel liver and sporozoite-stage P. falciparum antigen, referred to as LSA-5. This antigen is highly antigenic and the prevalence of antibodies in subjects living in endemic areas is extremely high (ca. 90%). The invention concerns antigenic peptides, mixtures thereof, or polypeptides, mixotopes and conjugates comprising part of the sequence of LSA-5, as well as immunogenic compositions, vaccines and kits comprising these.
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