Invention Grant
- Patent Title: Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
- Patent Title (中): 用于施用水溶性，阳离子和两亲药物活性物质的药物递送系统
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Application No.: US12809259Application Date: 2008-12-18
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Publication No.: US08765173B2Publication Date: 2014-07-01
- Inventor: Julian Aleksov , Igor Lokot
- Applicant: Julian Aleksov , Igor Lokot
- Applicant Address: GB London, Greater London
- Assignee: Ardenia Investments, Ltd.
- Current Assignee: Ardenia Investments, Ltd.
- Current Assignee Address: GB London, Greater London
- Agency: Renner, Otto, Boisselle & Sklar, LLP
- Priority: WOPCT/SE2007/001129 20071219
- International Application: PCT/SE2008/051516 WO 20081218
- International Announcement: WO2009/078803 WO 20090625
- Main IPC: A61K9/48
- IPC: A61K9/48
Abstract:
A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises poorly water soluble nanoparticles formed by the API together with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.
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