Invention Grant
US08765406B2 Engineered E2 for increasing the content of free LYS11-linked ubiquitin
失效
设计E2用于增加游离LYS11连接的泛素的含量
- Patent Title: Engineered E2 for increasing the content of free LYS11-linked ubiquitin
- Patent Title (中): 设计E2用于增加游离LYS11连接的泛素的含量
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Application No.: US13670594Application Date: 2012-11-07
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Publication No.: US08765406B2Publication Date: 2014-07-01
- Inventor: David Komander , Anja Bremm
- Applicant: David Komander , Anja Bremm
- Applicant Address: GB Swindon
- Assignee: Medical Research Council
- Current Assignee: Medical Research Council
- Current Assignee Address: GB Swindon
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Deborah L. Lu
- Priority: GB1007704.8 20100507
- Main IPC: C12N9/48
- IPC: C12N9/48
Abstract:
The invention provides a chimeric E2 enzyme comprising a Ubc domain fused to a heterologous ubiquitin binding domain (UBD). The chimeric enzymes of the invention may be useful in producing elevated levels of free polyubiquitin.
Public/Granted literature
- US20130065273A1 Engineered E2 For Increasing The Content Of Free LYS11-Linked Ubiquitin Public/Granted day:2013-03-14
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