Invention Grant
US08765409B2 Efficient production of heterologous proteins using mannosyl transferase inhibitors
有权
使用甘露糖基转移酶抑制剂有效生产异源蛋白
- Patent Title: Efficient production of heterologous proteins using mannosyl transferase inhibitors
- Patent Title (中): 使用甘露糖基转移酶抑制剂有效生产异源蛋白
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Application No.: US13588022Application Date: 2012-08-17
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Publication No.: US08765409B2Publication Date: 2014-07-01
- Inventor: Ranjit Desai , Lihu Yang
- Applicant: Ranjit Desai , Lihu Yang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C07D277/36
Abstract:
Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.
Public/Granted literature
- US20130316398A1 EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS Public/Granted day:2013-11-28
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