Invention Grant
- Patent Title: Cell cultivation process
- Patent Title (中): 细胞培养过程
-
Application No.: US13643996Application Date: 2011-04-25
-
Publication No.: US08765413B2Publication Date: 2014-07-01
- Inventor: Christoph E. Joosten , Christian Leist , Jörg Schmidt
- Applicant: Christoph E. Joosten , Christian Leist , Jörg Schmidt
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Andrew Holmes
- International Application: PCT/EP2011/056507 WO 20110425
- International Announcement: WO2011/134919 WO 20111103
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K16/00 ; C07K14/005 ; C12N15/81
Abstract:
This invention relates to a cell culture process for the production of polypeptides in mammalian CHO cells characterized by one or more temperature and pH shifts which are adjusted in respect to their timing and step size to reduce cell death, increase product yield and improve product quality.
Public/Granted literature
- US20130130316A1 CELL CULTIVATION PROCESS Public/Granted day:2013-05-23
Information query
IPC分类:
