Invention Grant
- Patent Title: DNA polymerases with increased 3′-mismatch discrimination
- Patent Title (中): 具有增加的3'-不匹配鉴别的DNA聚合酶
-
Application No.: US13180225Application Date: 2011-07-11
-
Publication No.: US08765436B2Publication Date: 2014-07-01
- Inventor: Keith Bauer , Fred Reichert , Thomas W. Myers
- Applicant: Keith Bauer , Fred Reichert , Thomas W. Myers
- Applicant Address: US CA Pleasanton
- Assignee: Roche Molecular Systems, Inc.
- Current Assignee: Roche Molecular Systems, Inc.
- Current Assignee Address: US CA Pleasanton
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12N15/54

Abstract:
Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
Public/Granted literature
- US20120208240A1 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION Public/Granted day:2012-08-16
Information query