Invention Grant
US08765437B2 Manufacture of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase and uses thereof
有权
活性高度磷酸化人N-乙酰半乳糖胺-6-硫酸酯酶的制备及其用途
- Patent Title: Manufacture of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase and uses thereof
- Patent Title (中): 活性高度磷酸化人N-乙酰半乳糖胺-6-硫酸酯酶的制备及其用途
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Application No.: US13188907Application Date: 2011-07-22
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Publication No.: US08765437B2Publication Date: 2014-07-01
- Inventor: Vish Koppaka , Michel Claude Vellard , Augustus O. Okhamafe , Kidisti Araya
- Applicant: Vish Koppaka , Michel Claude Vellard , Augustus O. Okhamafe , Kidisti Araya
- Applicant Address: US CA Novato
- Assignee: Biomarin Pharmaceutical Inc.
- Current Assignee: Biomarin Pharmaceutical Inc.
- Current Assignee Address: US CA Novato
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A61K38/46
- IPC: A61K38/46 ; A61P3/00 ; C12N9/16 ; C12N5/04 ; A61K38/00
Abstract:
This invention provides compositions of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase (GALNS), and pharmaceutical compositions and formulations thereof, methods of producing and purifying GALNS, and its use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the GALNS enzyme, e.g., Mucopolysaccharidosis IVa (MPS IVa or Morquio A syndrome).
Public/Granted literature
- US20120189605A1 MANUFACTURE OF ACTIVE HIGHLY PHOSPHORYLATED HUMAN N-ACETYLGALACTOSAMINE-6-SULFATASE AND USES THEREOF Public/Granted day:2012-07-26
Information query
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