Invention Grant
US08765443B2 Crystals of human topoisomerase II-DNA binary complex, methods for preparing the same and uses thereof
有权
人拓扑异构酶II-DNA二元复合物的晶体，其制备方法及其用途
- Patent Title: Crystals of human topoisomerase II-DNA binary complex, methods for preparing the same and uses thereof
- Patent Title (中): 人拓扑异构酶II-DNA二元复合物的晶体，其制备方法及其用途
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Application No.: US13556687Application Date: 2012-07-24
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Publication No.: US08765443B2Publication Date: 2014-07-01
- Inventor: Nei-Li Chan , Tsai-Kun Li , Chyuan-Chuan Wu , Ying-Ren Wang
- Applicant: Nei-Li Chan , Tsai-Kun Li , Chyuan-Chuan Wu , Ying-Ren Wang
- Applicant Address: TW Taipei
- Assignee: National Taiwan University
- Current Assignee: National Taiwan University
- Current Assignee Address: TW Taipei
- Agency: Bacon & Thomas, PLLC
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N9/90 ; C07H15/252 ; G01N23/20
Abstract:
Disclosed herein are a crystal of a human TOPII (hTOPII)-DNA binary complex, the method for preparing the same and the use thereof. The hTOPII-DNA binary complex includes an hTOPII portion that contains an hTOPII core domain (hTOPIIcore), and a synthetic double-stranded DNA in complex with the hTOPII portion. The synthetic double-stranded DNA has a first DNA strand comprising nucleotide positions 3 to 20 of the sequence of 5′-NNNCCGAGCNNNNGCTCGGNNN-3′ (SEQ ID NO: 1), wherein N is any one of adenine, thymine, cytosine, or guanine, and a second DNA strand complementary to the first DNA strand.
Public/Granted literature
- US20130018180A1 CRYSTALS OF HUMAN TOPOISOMERASE II-DNA BINARY COMPLEX, METHODS FOR PREPARING THE SAME AND USES THEREOF Public/Granted day:2013-01-17
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