The present invention relates to methods and devices to obtain multicellular arrangements in stable, stationary and reproducible spatial configuration, and optionally with controlled internal cell organization, methods for preparing such devices, methods for studying the cells' shapes, the cells' architectures, the cells' mechanical equilibrium, the cell-cell interaction, the cell movement and migration, the cell differentiation, the global internal cells' organizations, the cells' polarities and division, and/or any function of cells, methods for screening compounds of interest which enhance or inhibit specific cell functions.