Invention Grant
- Patent Title: Glycosylated GLP-1 peptide
- Patent Title (中): 糖基化GLP-1肽
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Application No.: US12999654Application Date: 2009-06-15
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Publication No.: US08765669B2Publication Date: 2014-07-01
- Inventor: Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
- Applicant: Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
- Applicant Address: JP Kyoto
- Assignee: Glytech, Inc.
- Current Assignee: Glytech, Inc.
- Current Assignee Address: JP Kyoto
- Agency: Osha Liang LLP
- Priority: JP2008-157583 20080617; JP2008-326609 20081222
- International Application: PCT/JP2009/002709 WO 20090615
- International Announcement: WO2009/153960 WO 20091223
- Main IPC: A61K38/26
- IPC: A61K38/26 ; A61P3/10 ; A61P7/12 ; C07K14/605 ; C07K1/00 ; C07K14/00 ; C07K17/00
Abstract:
Oligosaccharide chain added GLP-1 peptides are more stable in blood and more active in controlling blood-sugar levels than GLP-1 peptides without added oligosaccharides. Oligosaccharide chain added GLP-1 peptides having GLP-1 activity include at least one or at least two amino acids each substituted with an oligosaccharide chain added amino acid in GLP-1; a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or a GLP-1 analog. Oligosaccharide chain added GLP-1 peptides with at least one amino acid substituted with an oligosaccharide chain added amino acid include an oligosaccharide chain with oligo hyaluronic acid. Oligosaccharide chain added amino acids include oligosaccharide chains attached to amino acids via linkers.
Public/Granted literature
- US20110195897A1 GLYCOSYLATED GLP-1 PEPTIDE Public/Granted day:2011-08-11
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