Invention Grant
US08765672B2 Method of modulating release of biomolecules having heparin-binding affinity
有权
调节具有肝素结合亲和力的生物分子的释放方法
- Patent Title: Method of modulating release of biomolecules having heparin-binding affinity
- Patent Title (中): 调节具有肝素结合亲和力的生物分子的释放方法
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Application No.: US13550136Application Date: 2012-07-16
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Publication No.: US08765672B2Publication Date: 2014-07-01
- Inventor: Giyoong Tae , Bo-young Kim , Kihak Gwon , Young Ha Kim , Myung-Han Yoon
- Applicant: Giyoong Tae , Bo-young Kim , Kihak Gwon , Young Ha Kim , Myung-Han Yoon
- Applicant Address: KR Buk-Gu, Gwangju
- Assignee: Gwangju Institute of Science and Technology
- Current Assignee: Gwangju Institute of Science and Technology
- Current Assignee Address: KR Buk-Gu, Gwangju
- Agency: Nath, Goldberg & Meyer
- Agent Joshua B. Goldberg
- Priority: KR10-2011-0115708 20111108
- Main IPC: C07K14/50
- IPC: C07K14/50 ; C07K17/06 ; C07K17/14
Abstract:
The present invention relates to a method of modulating a release of biomolecules having heparin-binding affinity, and more specifically, to a method of modulating a release of biomolecules having heparin-binding affinity, using thiolated heparin adsorbed on metal surface. According to the present invention, it is possible to modulate various biomolecules having heparin-binding affinity such as growth factors spatiotemporally by external electrical stimulations, without causing cytotoxicity and having deteriorating effects on cell activity. Thus, the present invention can be applied for various biomedical and biotechnical fields including drug delivery, biosensor, and cell culture.
Public/Granted literature
- US20130112544A1 METHOD OF MODULATING RELEASE OF BIOMOLECULES HAVING HEPARIN-BINDING AFFINITY Public/Granted day:2013-05-09
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