Invention Grant
US08765699B2 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
有权
寡核糖核苷酸及其用于治疗脱发，急性肾衰竭和其它疾病的方法
- Patent Title: Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
- Patent Title (中): 寡核糖核苷酸及其用于治疗脱发，急性肾衰竭和其它疾病的方法
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Application No.: US11237598Application Date: 2005-09-27
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Publication No.: US08765699B2Publication Date: 2014-07-01
- Inventor: Elena Feinstein , Daniel Zurr , Shai Ehrlich
- Applicant: Elena Feinstein , Daniel Zurr , Shai Ehrlich
- Applicant Address: US CA Fremont
- Assignee: Quark Pharmaceuticals, Inc.
- Current Assignee: Quark Pharmaceuticals, Inc.
- Current Assignee Address: US CA Fremont
- Agency: Cooper & Dunham LLP
- Agent John P. White
- Main IPC: C12N15/113
- IPC: C12N15/113
Abstract:
The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
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