Invention Grant
- Patent Title: Azaspirohexanones
- Patent Title (中): 阿扎苯甲酮
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Application No.: US13166895Application Date: 2011-06-23
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Publication No.: US08765744B2Publication Date: 2014-07-01
- Inventor: Frank Himmelsbach
- Applicant: Frank Himmelsbach
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; David L. Kershner
- Priority: EP10167325 20100625; EP10167958 20100630
- Main IPC: C07D413/08
- IPC: C07D413/08 ; A61K31/537

Abstract:
The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, R7, A, Z and m are as defined herein. The compounds of formula (I) are inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
Public/Granted literature
- US20120190675A1 Azaspirohexanones Public/Granted day:2012-07-26
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