Invention Grant
US08765748B2 Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer
有权
吲唑基,苯并咪唑基,苯并三唑基取代的二氢吲哚酮衍生物作为可用于治疗癌症的激酶抑制剂
- Patent Title: Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer
- Patent Title (中): 吲唑基,苯并咪唑基,苯并三唑基取代的二氢吲哚酮衍生物作为可用于治疗癌症的激酶抑制剂
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Application No.: US12808961Application Date: 2008-12-19
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Publication No.: US08765748B2Publication Date: 2014-07-01
- Inventor: Heinz W. Pauls , Bryan T. Forrest , Radoslaw Laufer , Miklos Feher , Peter Brent Sampson , Guohua Pan , Sze-Wan Li , Yong Liu
- Applicant: Heinz W. Pauls , Bryan T. Forrest , Radoslaw Laufer , Miklos Feher , Peter Brent Sampson , Guohua Pan , Sze-Wan Li , Yong Liu
- Applicant Address: CA Toronto
- Assignee: University Health Network
- Current Assignee: University Health Network
- Current Assignee Address: CA Toronto
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- International Application: PCT/CA2008/002227 WO 20081219
- International Announcement: WO2009/079767 WO 20090702
- Main IPC: A61P35/00
- IPC: A61P35/00 ; A61P35/02 ; C07D401/14 ; C07D403/06 ; C07D403/12 ; C07D403/10 ; C07D403/14 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; A61K31/416 ; A61K31/4192 ; A61K31/4184 ; A61K31/4439 ; A61K31/496 ; A61K31/437 ; A61K31/5377

Abstract:
The present invention is directed to a compound is represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.
Public/Granted literature
Information query
IPC分类:
A | 人类生活必需 |
A61 | 医学或兽医学;卫生学 |
A61P | 化合物或药物制剂的特定治疗活性 |
A61P35/00 | 抗肿瘤药 |