Invention Grant
US08765749B2 1,6-disubstituted indole compounds as protein kinase inhibitors
有权
1,6-二取代的吲哚化合物作为蛋白激酶抑制剂
- Patent Title: 1,6-disubstituted indole compounds as protein kinase inhibitors
- Patent Title (中): 1,6-二取代的吲哚化合物作为蛋白激酶抑制剂
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Application No.: US13504355Application Date: 2010-10-20
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Publication No.: US08765749B2Publication Date: 2014-07-01
- Inventor: Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
- Applicant: Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
- Applicant Address: KR Seoul
- Assignee: Korea Institute of Science and Technology
- Current Assignee: Korea Institute of Science and Technology
- Current Assignee Address: KR Seoul
- Agency: Staas & Halsey LLP
- Priority: KR10-2009-0102359 20091027
- International Application: PCT/KR2010/007205 WO 20101020
- International Announcement: WO2011/052923 WO 20110505
- Main IPC: C07D403/04
- IPC: C07D403/04 ; A61K31/404 ; C07D403/14 ; C07D405/14
Abstract:
Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
Public/Granted literature
- US20120271048A1 NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS Public/Granted day:2012-10-25
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