Invention Grant
- Patent Title: Compounds useful as inhibitors of ATR kinase
- Patent Title (中): 可用作ATR激酶抑制剂的化合物
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Application No.: US13631730Application Date: 2012-09-28
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Publication No.: US08765751B2Publication Date: 2014-07-01
- Inventor: Jean-Damien Charrier , Stephen Clinton Young , Christopher John Davis , John Studley
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agent Jennifer G. Che
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A61K31/5377 ; C07D413/14 ; C07D413/04 ; C07D413/10
Abstract:
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein. Additionally, the present invention also relates to novel processes for the production of various morpoholine based intermediates.
Public/Granted literature
- US20130089624A1 Compounds Useful as Inhibitors of ATR Kinase Public/Granted day:2013-04-11
Information query
