Invention Grant
- Patent Title: Monocyclic CGRP receptor antagonists
- Patent Title (中): 单环CGRP受体拮抗剂
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Application No.: US12934208Application Date: 2009-03-24
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Publication No.: US08765759B2Publication Date: 2014-07-01
- Inventor: Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
- Applicant: Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent H. Eric Fischer; John C. Todaro
- International Application: PCT/US2009/038013 WO 20090324
- International Announcement: WO2009/120652 WO 20091001
- Main IPC: A61K31/437
- IPC: A61K31/437 ; A61K31/497 ; A61K31/4985
Abstract:
The present invention is directed to compounds of the formula: (wherein variables A1, A2, A3, G1, G2, G3, G4, J, Ea, Eb, Ec, R6, R7, and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Public/Granted literature
- US20110021516A1 MONOCYCLIC CGRP RECEPTOR ANTAGONISTS Public/Granted day:2011-01-27
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