Invention Grant
- Patent Title: Bis-carbazole DNA intercalating agents for antitumor therapy
- Patent Title (中): 用于抗肿瘤治疗的双咔唑DNA插层剂
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Application No.: US13002772Application Date: 2009-07-02
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Publication No.: US08765781B2Publication Date: 2014-07-01
- Inventor: Gordon W. Gribble , Dmity A. Androsov
- Applicant: Gordon W. Gribble , Dmity A. Androsov
- Applicant Address: US NH Hanover
- Assignee: Trustees of Dartmouth College
- Current Assignee: Trustees of Dartmouth College
- Current Assignee Address: US NH Hanover
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US2009/049560 WO 20090702
- International Announcement: WO2010/005870 WO 20100114
- Main IPC: A61K31/473
- IPC: A61K31/473 ; A61K31/4709 ; C07D401/12
Abstract:
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an antitumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided.
Public/Granted literature
- US20110118296A1 Bis-Carbazole DNA Intercalating Agents for Antitumor Therapy Public/Granted day:2011-05-19
Information query
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