Invention Grant
- Patent Title: Tricyclic inhibitors of hydroxysteroid dehydrogenases
- Patent Title (中): 羟基类固醇脱氢酶的三环抑制剂
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Application No.: US12664137Application Date: 2008-06-11
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Publication No.: US08765788B2Publication Date: 2014-07-01
- Inventor: Jay P. Powers , Daqing Sun , Xuelei Yan , Lisa Julian , Felix Gonzalez Lopez De Turiso
- Applicant: Jay P. Powers , Daqing Sun , Xuelei Yan , Lisa Julian , Felix Gonzalez Lopez De Turiso
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Elsa D. Lemoine
- International Application: PCT/US2008/007269 WO 20080611
- International Announcement: WO2008/156601 WO 20081224
- Main IPC: A61K31/445
- IPC: A61K31/445 ; A61K31/425 ; A61K31/42
Abstract:
The present invention provides tricyclic compounds according to formula (I): (I) where R1, R2, R3, W, X, Y, Z, m, n, and p are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11-HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions.
Public/Granted literature
- US20100280073A1 TRICYCLIC INHIBITORS OF HYDROXYSTEROID DEHYDROGENASES Public/Granted day:2010-11-04
Information query
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