Invention Grant
US08765820B2 Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
有权
作为组蛋白脱甲基酶LSD1和/或LSD2的抑制剂的苯丙氨酸衍生物
- Patent Title: Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
- Patent Title (中): 作为组蛋白脱甲基酶LSD1和/或LSD2的抑制剂的苯丙氨酸衍生物
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Application No.: US13641715Application Date: 2011-04-15
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Publication No.: US08765820B2Publication Date: 2014-07-01
- Inventor: Saverio Minucci , Antonello Mai , Andrea Mattevi
- Applicant: Saverio Minucci , Antonello Mai , Andrea Mattevi
- Applicant Address: IT Rome IT Milan IT Pavia IT Milan
- Assignee: Universita Degli Studi di Roma “La Sapienza”,Fondazione IEO,Universita Degli Studi di Pavia,Universita Degli Studi di Milano
- Current Assignee: Universita Degli Studi di Roma “La Sapienza”,Fondazione IEO,Universita Degli Studi di Pavia,Universita Degli Studi di Milano
- Current Assignee Address: IT Rome IT Milan IT Pavia IT Milan
- Agency: Lucas & Mercanti, LLP
- International Application: PCT/EP2011/055990 WO 20110415
- International Announcement: WO2011/131576 WO 20111027
- Main IPC: A61K31/015
- IPC: A61K31/015 ; C07C329/00
Abstract:
Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
Public/Granted literature
- US20130035377A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 Public/Granted day:2013-02-07
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