Invention Grant
- Patent Title: Metastin derivatives and use thereof
- Patent Title (中): Metastin衍生物及其用途
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Application No.: US12446142Application Date: 2007-10-24
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Publication No.: US08765909B2Publication Date: 2014-07-01
- Inventor: Taiji Asami , Naoki Nishizawa
- Applicant: Taiji Asami , Naoki Nishizawa
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Edwards Wildman Palmer LLP
- Agent David G. Conlin
- Priority: JP2006-290536 20061025; JP2007-021387 20070131; JP2007-221911 20070828
- International Application: PCT/JP2007/071169 WO 20071024
- International Announcement: WO2008/050897 WO 20080502
- Main IPC: C07K7/02
- IPC: C07K7/02 ; A61K38/08 ; A61P35/00
Abstract:
The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic hormone secretion stimulating activity, sex hormone secretion stimulating activity, etc.). By substituting the constituent amino acids of metastin with specific amino acids, the metastin derivatives of the present invention achieve more improved blood stability, solubility, etc., reduced gelation tendency, improved pharmacokinetics, as well as exhibit an excellent cancer metastasis suppressing activity or a cancer growth suppressing activity. The metastin derivatives of the present invention also have a gonadotropic hormone secretion suppressing activity, sex hormone secretion suppressing activity, etc.
Public/Granted literature
- US20110059888A1 METASTIN DERIVATIVES AND USE THEREOF Public/Granted day:2011-03-10
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