Invention Grant
US08765910B2 Method for amidating polypeptides with basic amino acid C-terminals by means of specific endoproteases
有权
通过特异性内切蛋白酰胺化具有碱性氨基酸C-末端的多肽的方法
- Patent Title: Method for amidating polypeptides with basic amino acid C-terminals by means of specific endoproteases
- Patent Title (中): 通过特异性内切蛋白酰胺化具有碱性氨基酸C-末端的多肽的方法
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Application No.: US12065643Application Date: 2006-09-13
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Publication No.: US08765910B2Publication Date: 2014-07-01
- Inventor: Sebastian Rissom , Paul Habermann , Christophe Salagnad , Frank Zocher , Laure Landric-Burtin
- Applicant: Sebastian Rissom , Paul Habermann , Christophe Salagnad , Frank Zocher , Laure Landric-Burtin
- Applicant Address: DE Frankfurt am Main
- Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: DE102005046113 20050927
- International Application: PCT/EP2006/008903 WO 20060913
- International Announcement: WO2007/036299 WO 20070405
- Main IPC: C07K1/36
- IPC: C07K1/36 ; C07K1/107 ; C07K14/00 ; A61K38/16 ; C07K1/00
Abstract:
The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.
Public/Granted literature
- US20100311112A1 METHOD FOR AMIDATING POLYPEPTIDES WITH BASIC AMINO ACID C-TERMINALS BY MEANS OF SPECIFIC ENDOPROTEASES Public/Granted day:2010-12-09
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