Invention Grant
US08765913B2 Human frizzled (FZD) receptor polypeptides and methods of use thereof for treating cancer and inhibiting growth of tumor cells
有权
人类卷曲（FZD）受体多肽及其用于治疗癌症并抑制肿瘤细胞生长的方法
- Patent Title: Human frizzled (FZD) receptor polypeptides and methods of use thereof for treating cancer and inhibiting growth of tumor cells
- Patent Title (中): 人类卷曲（FZD）受体多肽及其用于治疗癌症并抑制肿瘤细胞生长的方法
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Application No.: US13667191Application Date: 2012-11-02
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Publication No.: US08765913B2Publication Date: 2014-07-01
- Inventor: Austin L. Gurney , John Lewicki , Sanjeev Satyal , Timothy Hoey
- Applicant: OncoMed Pharmaceuticals, Inc.
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00 ; C07K17/00 ; C12P21/06 ; C12N1/20 ; C12N15/00 ; C12N5/00 ; C12N5/02 ; C12N15/74 ; A61K38/00 ; A61P35/00 ; C12P21/08 ; C07H21/04
Abstract:
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth.
Public/Granted literature
- US20130273044A1 Compositions and Methods for Diagnosing and Treating Cancer Public/Granted day:2013-10-17
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