Invention Grant
- Patent Title: Modified coagulation factor VIIa with extended half-life
- Patent Title (中): 改性凝血因子Ⅶa具有延长的半衰期
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Application No.: US12223616Application Date: 2007-02-03
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Publication No.: US08765915B2Publication Date: 2014-07-01
- Inventor: Thomas Weimer , Stefan Schulte , Ulrich Kronthaler , Wiegand Lang , Uwe Liebing , Wilfried Wormsbächer
- Applicant: Thomas Weimer , Stefan Schulte , Ulrich Kronthaler , Wiegand Lang , Uwe Liebing , Wilfried Wormsbächer
- Applicant Address: DE Marburg
- Assignee: CSL Behring GmbH
- Current Assignee: CSL Behring GmbH
- Current Assignee Address: DE Marburg
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: EP06002359 20060206
- International Application: PCT/EP2007/000937 WO 20070203
- International Announcement: WO2007/090584 WO 20070816
- Main IPC: A61K38/35
- IPC: A61K38/35 ; A61K38/38 ; C07K14/745 ; C07K14/76 ; C07K14/765 ; C12N9/64 ; A61K38/00

Abstract:
The present invention relates to the fields of Factor VII (FVII) and Factor VIIa (FVIIa) albumin linked polypeptides. More specifically, the invention relates to cDNA sequences coding for human Factor VII and Factor VIIa and derivatives genetically fused to a cDNA coding for human serum albumin which may be linked by oligonucleotides which code for intervening peptidic linkers such encoded derivatives exhibiting improved stability and extended functional plasma half-life, recombinant expression vectors containing such cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and prolonged shelf-life and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA sequences.
Public/Granted literature
- US20090298760A1 Modified Coagulation Factor VIIa With Extended Half-Life Public/Granted day:2009-12-03
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