Invention Grant
- Patent Title: Processes of synthesizing dihydropyridophthalazinone derivatives
- Patent Title (中): 合成二氢吡啶并酞嗪酮衍生物的方法
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Application No.: US13023140Application Date: 2011-02-08
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Publication No.: US08765945B2Publication Date: 2014-07-01
- Inventor: Bing Wang , Daniel Chu , Yongbo Liu , Quan Jiang , Lei Lu
- Applicant: Bing Wang , Daniel Chu , Yongbo Liu , Quan Jiang , Lei Lu
- Applicant Address: US CA Novato
- Assignee: BioMarin Pharmaceutical Inc.
- Current Assignee: BioMarin Pharmaceutical Inc.
- Current Assignee Address: US CA Novato
- Agency: Jones Day
- Main IPC: C07D237/36
- IPC: C07D237/36
Abstract:
Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.
Public/Granted literature
- US20110196153A1 PROCESSES OF SYNTHESIZING DIHYDROPYRIDOPHTHALAZINONE DERIVATIVES Public/Granted day:2011-08-11
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