Invention Grant
US08765955B2 Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts
有权
使用双功能胡萝卜素 - 生物碱类催化剂的不对称醛醇醛添加剂
- Patent Title: Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts
- Patent Title (中): 使用双功能胡萝卜素 - 生物碱类催化剂的不对称醛醇醛添加剂
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Application No.: US11442667Application Date: 2006-05-26
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Publication No.: US08765955B2Publication Date: 2014-07-01
- Inventor: Li Deng , Hongming Li
- Applicant: Li Deng , Hongming Li
- Applicant Address: US MA Waltham
- Assignee: Brandeis University
- Current Assignee: Brandeis University
- Current Assignee Address: US MA Waltham
- Agency: Foley Hoag LLP
- Agent Dana M. Gordon
- Main IPC: C07D453/04
- IPC: C07D453/04
Abstract:
One aspect of the present invention relates to asymmetric catalytic nitroaldol (Henry) reactions with ketones as the electrophilic component. In one embodiment, the present invention relates to asymmetric nitroaldol reactions with α-keto esters catalyzed by a new C6′-OH cinchona alkaloid catalyst. In certain embodiments, this reaction is operationally simple and affords high enantioselectivity as well as good to excellent yield for an exceptionally broad range of α-keto esters.
Public/Granted literature
- US20070112199A1 Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts Public/Granted day:2007-05-17
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