Invention Grant
US08765972B2 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides with selective PARP-1 inhibition
有权
具有选择性PARP-1抑制的3-氧代-2,3-二氢-1H-异吲哚-4-甲酰胺
- Patent Title: 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides with selective PARP-1 inhibition
- Patent Title (中): 具有选择性PARP-1抑制的3-氧代-2,3-二氢-1H-异吲哚-4-甲酰胺
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Application No.: US13383611Application Date: 2010-07-06
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Publication No.: US08765972B2Publication Date: 2014-07-01
- Inventor: Gianluca Mariano Enrico Papeo , Alina Anatolievna Busel , Elena Casale , Alexander Khvat , Mikhail Yurievitch Krasavin , Paolo Orsini , Helena Posteri , Alessandra Scolaro
- Applicant: Gianluca Mariano Enrico Papeo , Alina Anatolievna Busel , Elena Casale , Alexander Khvat , Mikhail Yurievitch Krasavin , Paolo Orsini , Helena Posteri , Alessandra Scolaro
- Applicant Address: IT Nerviano (MI)
- Assignee: Nerviano Medical Sciences S.r.l.
- Current Assignee: Nerviano Medical Sciences S.r.l.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP09165446 20090714
- International Application: PCT/EP2010/059668 WO 20100706
- International Announcement: WO2011/006803 WO 20110120
- Main IPC: A61K31/40
- IPC: A61K31/40 ; C07D209/44
Abstract:
There are provided substituted 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
Public/Granted literature
- US20120245143A1 3-0X0-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES WITH SELECTIVE PARP-1 INHIBITION Public/Granted day:2012-09-27
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