Invention Grant
US08765973B2 Etomidate analogues that do not inhibit adrenocortical steroid synthesis
有权
不抑制肾上腺皮质类固醇合成的依托咪酯类似物
- Patent Title: Etomidate analogues that do not inhibit adrenocortical steroid synthesis
- Patent Title (中): 不抑制肾上腺皮质类固醇合成的依托咪酯类似物
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Application No.: US13382544Application Date: 2010-07-08
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Publication No.: US08765973B2Publication Date: 2014-07-01
- Inventor: Douglas E. Raines , Joseph F. Cotten , Stuart A. Forman , Keith W. Miller , Syed S. Husain , Gregory D. Cuny
- Applicant: Douglas E. Raines , Joseph F. Cotten , Stuart A. Forman , Keith W. Miller , Syed S. Husain , Gregory D. Cuny
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- International Application: PCT/US2010/041379 WO 20100708
- International Announcement: WO2011/005969 WO 20110113
- Main IPC: C07D207/337
- IPC: C07D207/337 ; A61K31/40

Abstract:
The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; R4 and R5 are independently H, halogen, CN or CF3; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.
Public/Granted literature
- US20130079381A1 ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS Public/Granted day:2013-03-28
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