Invention Grant
- Patent Title: Hydroxylated contrast enhancement agents and imaging method
- Patent Title (中): 羟基化对比增强剂和成像方法
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Application No.: US13077746Application Date: 2011-03-31
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Publication No.: US08765977B2Publication Date: 2014-07-01
- Inventor: Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine Roberts
- Applicant: Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine Roberts
- Applicant Address: US NY Niskayuna
- Assignee: General Electric Company
- Current Assignee: General Electric Company
- Current Assignee Address: US NY Niskayuna
- Agent Andrew J. Caruso
- Main IPC: C07D319/08
- IPC: C07D319/08 ; C07D309/30

Abstract:
A method of diagnostic imaging is disclosed comprising administering a medical formulation to a subject, the formulation comprising a contrast enhancement agent having structure I and salts thereof wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions; and one or more pharmaceutically acceptable carriers and excipients. The subject is subjected to a diagnostic imaging technique such as magnetic resonance imaging. The technique may be used in a variety of diagnostic imaging regimes, such as imaging of circulatory systems, genitourinary systems, hepatobiliary systems, central nervous systems, tumors, and abscesses among others.
Public/Granted literature
- US20110243858A1 HYDROXYLATED CONTRAST ENHANCEMENT AGENTS AND IMAGING METHOD Public/Granted day:2011-10-06
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