A transparent scintillator panel including an extruded scintillation layer comprising a thermoplastic polyolefin and a scintillator material, wherein the transparent scintillator panel has an intrinsic MTF at least 5% greater than the iH50 of a solvent-coated DRZ+ screen. Also disclosed is a scintillation detection system including a transparent scintillator panel comprising an extruded scintillation layer comprising a thermoplastic olefin and a scintillator material; and at least one photodetector coupled to the transparent scintillator panel, wherein at least one photodetector is configured to detect photons generated from the transparent scintillator panel. Further disclosed is a method of making a transparent scintillator panel including providing thermoplastic particles comprising at least one thermoplastic polyolefin and a scintillator material; and melt extruding the thermoplastic particles to form an extruded scintillation layer.