A touch panel and a differential detection method thereof are disclosed. A controller provides a driving signal to the i-th scan electrode. During providing the driving signal to the i-th scan electrode, the controller senses the feature difference value between two neighboring sensing electrodes within the plural sensing electrodes, and senses the feature difference value ΔCi between the k-th sensing electrode within the sensing electrodes and a reference feature value, in which the feature difference values between the j-th sensing electrode and the (j+1)-th sensing electrode is represented by ΔC(i,j). The controller set the feature value of a base sensing point within a plurality of sensing points of the touch panel as a base feature value, and use the base feature value, the feature difference values ΔCi and the feature difference values ΔC(i,j) to calculate the feature values of the sensing points.