A method is provided for operating a nuclear reactor. The method includes operating the nuclear reactor for an initial cycle during which a core contains initial nuclear fuel assemblies; then operating the nuclear reactor for transition cycles, at least some of the initial nuclear fuel assemblies being progressively replaced, during the replacement steps preceding the transition cycles, with transition nuclear fuel assemblies or with plutonium-equilibrium nuclear fuel assemblies; and then operating the nuclear reactor for at least one plutonium equilibrium cycle during which the core contains only plutonium-equilibrium nuclear fuel assemblies.